Neurexin, Neuroligin and Wishful Thinking coordinate synaptic cytoarchitecture and growth at neuromuscular junctions
نویسندگان
چکیده
منابع مشابه
Drosophila Neuroligin 1 Promotes Growth and Postsynaptic Differentiation at Glutamatergic Neuromuscular Junctions
Precise apposition of presynaptic and postsynaptic domains is a fundamental property of all neuronal circuits. Experiments in vitro suggest that Neuroligins and Neurexins function as key regulatory proteins in this process. In a genetic screen, we recovered several mutant alleles of Drosophila neuroligin 1 (dnlg1) that cause a severe reduction in bouton numbers at neuromuscular junctions (NMJs)...
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BACKGROUND Neurexin is a synaptic cell adhesion protein critical for synapse formation and function. Mutations in neurexin and neurexin-interacting proteins have been implicated in several neurological diseases. Previous studies have described Drosophila neurexin mutant phenotypes in third instar larvae and adults. However, the expression and function of Drosophila neurexin early in synapse dev...
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Building arborisations of the right size and shape is fundamental for neural network function. Live imaging in vertebrate brains strongly suggests that nascent synapses are critical for branch growth during development. The molecular mechanisms underlying this are largely unknown. Here we present a novel system in Drosophila for studying the development of complex arborisations live, in vivo du...
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Every synaptogenesis begins with "synaptic target recognition," a cell-cell recognition event in which a neuron and its target stably adhere. Despite its importance in developing nervous systems, synaptic target recognition has been difficult to study in complex systems. The relatively simple and genetically accessible Drosophila NMJ model system provides a repertoire of target recognition cues...
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See online version for legend and references. The neuroligin-neurexin complex is a heterophilic adhesion system at neuronal synapses. Both neuroligins and neurexins have synaptogenic activities that organize pre-and postsynaptic compartments in a bidirectional manner. Multiple genes, alternative promoters, and extensive alternative splicing generate neuroligin and neurexin variants that may und...
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ژورنال
عنوان ژورنال: Molecular and Cellular Neuroscience
سال: 2017
ISSN: 1044-7431
DOI: 10.1016/j.mcn.2016.11.004